Anti Microsomal Antibody (AMA)

Clinical definition of the Anti Microsomal Antibody test
Antimicrosomal antibodies are autoantibodies, directed against the microsomes (in particular peroxidase) of the thyroid cells inside which they are found, leading to thyroiditis, tissue damage, and disruption of thyroid function. It is associated with autoimmune conditions can also be associated with thyroid disorders, such as Hashimoto's thyroiditis and Grave's disease.

Why is the Anti Microsomal Antibody test done?
This test measures the presence & the quantity of antithyroid microsomal antibodies in the blood. It is also done to diagnose, confirm and monitor the cause of thyroid problems and other autoimmune disorders.

What are the common signs/symptoms when the Anti Microsomal Antibody test is done?

  • Hypothyroidism
    • Weight
    • Gain
    • Fatigue
    • Goiter
    • Dry skin
    • Hair loss
    • Intolerance to cold
    • Constipation
  • Hyperthyroidism
    • Sweating
    • Rapid heart rate
    • Anxiety
    • Tremors
    • Fatigue
    • Difficulty sleeping
    • Sudden weight loss
    • Protruding eyes

What should I do before the Anti Microsomal Antibody test?

Specimen type

Specimen collection procedure

Preparatory instructions during specimen collection*

Serum (Blood Sample)

Venipuncture - Collection of blood from a vein, usually from the arm.

No Fasting Required.

No other special preparations required.

*Subjects suffering from any illness or on oral or injectable medications are advised to consult their physician prior to requesting any tests or procedures.

How do I interpret my Anti Microsomal Antibody test results?



0.0-9.0 IU/mL 


‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’                       

Diseases/conditions related to the Anti Microsomal Antibody test

  • Thyroiditis
  • Goiter 
  • Pernicious anemia
  • Hashimoto’s thyroiditis
  • Autoimmune hemolytic anemia
  • Granulomatous thyroiditis
  • Hashimoto's thyroiditis
  • Nontoxic nodular goiter
  • Rheumatoid arthritis
  • Sjogren syndrome
  • Systemic lupus erythematosus
  • Thyroid cancer
  • Autoimmune hepatitis
  • Increased risk of:
  • Miscarriage
  • Preeclampsia
  • Premature birth
  • In Vitro Fertilization Failure

Other tests related to the Anti Microsomal Antibody test

  • T3
  • T4
  • TSH
  • Thyroglobulin

Synonyms : Thyroid peroxidase antibody (TPOAb)