Creatinine

Clinical definition of the Creatinine test
Creatinine is transported to the kidneys via the bloodstream. The kidneys filter out most of the creatinine and dispose it off in the urine.
High levels of creatinine increase the risk of kidney damage, dehydration and heart problems causing increased heart trembling and difficulty in urinating. Other causes of high creatinine levels include urinary tract infections, hypertension, diabetes, kidney stones and continuous intake of antibiotics.
The other tests associated with the Creatinine tests are

  • Creatinine Clearance Test (CCT)
  • Protein-Creatinine Ratio (PCR)

Why is the Creatinine test done?
A blood and/or urine creatinine test is done to check the amount of Creatinine in them. It is usually used as an indicator of renal function and to monitor treatment for kidney disease.
Creatinine clearance test- This test compares the level of creatinine in urine with the creatinine level in the blood which may be useful in providing information on the normal functioning of the kidney. It is used to estimate the glomerular filtration rate (GFR).
Protein-Creatinine Ratio (PCR) - The concentration of protein in the urine is compared to the creatinine level in a spot urine sample. It may be used to monitor persistent. Proteinuria i.e. presence of an excess of serum proteins in the urine. The protein in the urine often causes the urine to become foamy.

What are the common signs/symptoms when the Creatinine test is done?
Symptoms of a kidney related disorder

  • Poor appetite
  • Fatigue
  • Lack of concentration
  • Trouble sleeping
  • Swelling or puffiness especially around the eyes or in the face, ankles, hands, feet abdomen wrists, abdomen and thighs
  • Foamy, bloody, or dark-colored Urine
  • Reduced urine output or change in the frequency of urination
  • Discomfort during urination (burning sensation)
  • Mid-back pain
  • Pain below the ribs (location of the kidneys)
  • High blood pressure

Who should do the Creatinine test (Target population)?
Persons showing the above signs & symptoms of a kidney disorder or those undergoing a treatment for kidney or liver disease.

What should I do before the Creatinine test?

Specimen type

Specimen collection procedure

Preparatory instructions before the test *

Serum

(Blood Sample)

Venipuncture

No special preparations required.

Urine

24-hour urine sample-Care must be taken to clean the genitals well before collection.

Follow these steps to get the sample

Day 1- The first morning urine sample on Day 1 must not be collected i.e. bladder must be emptied for the first time.

Note down the exact time of discarding the 1st urine sample.

All urine for the next 24 hours should be collected in the special container provided.

Day 2- collect the first morning urine of Day 2 into the same container, at the same time or within 10 minutes as that noted on the morning of Day 1.

Cap the container. Keep it in the refrigerator or a cool place during the collection period.

No special preparations required.

*Subjects suffering from any illness or on oral or injectable medications are advised to consult their physician prior to requesting any tests or procedures.

How do I interpret my Creatinine test results?

Reference Range*

Interpretation

Serum Creatinine

Male

0.6 to 1.3 mg/dL

Female

0.6 to 1.3 mg/dL

Children

 

New born

0.8 to 1.4 mg/dl

Infant

0.7-1.7 mg/dl

 

Boy (mg/dl)

Girl (mg/dl)

1 year

Upto 0.6

Upto 0.5

2-3 years

Upto 0.7

Upto 0.6

4-7 years

Upto 0.8

Upto 0.7

8-10 years

Upto 0.9

Upto 0.8

11-12 yrs

Upto 1.0

Upto 0.9

13-17 yrs

Upto 1.2

Upto 1.1

Urine Creatinine

Male

<150 mg/24 hours

Female

<250 mg/24 hours

Creatinine, 24 hours urine

 

Male

1000 to 2000 mg/day

Female

800 to 1800 mg/day

Children

800 to 2000 mg/day

Protein-Creatinine Ratio

Upto 0.2

Inference: Increased levels suggest diseases or conditions that affect the kidney function. Low levels are not usually a cause for concern. Can be seen with condition that results in decreased muscle mass.

‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’

Diseases/conditions related to the Creatinine test

  • Acute tubular necrosis
  • Diabetic nephropathy
  • Eclampsia 
  • Glomerulonephritis
  • Kidney failure
  • Muscular dystrophy
  • Preeclampsia 
  • Pyelonephritis
  • Rhabdomyolysis
  • Urinary tract obstruction
  • Muscular dystrophy (late stage)
  • Myasthenia gravis

Other tests related to the Creatinine test

  • Blood UreaNitrogen
  • Microalbumin
  • Creatinine
  • BUN/creatinine ratio
  • eGFR
  • Creatinine clearance
  • Urine Routine
  • Urine protein to creatinine ratio
  • Comprehensive Metabolic Panel
  • Basic Metabolic Panel
  • Cystatin C

Synonyms : Creatinine Clearance Test (CCT / CRCL), Protein-Creatinine ratio
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Creatinine (Serum)

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