Anti CCP (Antibody to Cyclic Citrullinated Peptide)

Clinical definition of the Anti - CCP
Anti- CCP which stands for anti-cyclic citrullinated peptide antibody (CCP) is a blood test to confirm a diagnosis of rheumatoid arthritis. This test detects the presence of citrulline antibodies in the blood. These autoantibodies are proteins produced by the immune system in response to perceived threat from citrulline. Conversion of arginine to citrulline plays a role in the autoimmune inflammatory process seen in the joints of those with Rheumatoid arthritis (RA). RA is a chronic systemic autoimmune disease that causes inflammation, pain, stiffness, and destructive changes in the hands, feet, and other joints throughout the body.

Why is the Anti - CCP test done?
Anti- CCP is carried out to diagnose rheumatoid arthritis (RA) and differentiate it from other types of arthritis and to evaluate the prognosis of persons with rheumatoid arthritis.

What are the common signs/symptoms when the Anti - CCP test is done?

  • Fatigue
  • Lack of appetite
  • Low grade fever
  • Pain
  • Stiffness
  • Destructive changes in the hands, feet, and other joints throughout the body
  • Joints frequently become red, swollen, painful, and tender
  • Symptoms in the hands include difficulty with simple tasks of daily living, such as turning door knobs and opening jars
  • Stiffness of the small joints of the feet which leads to painful walking especially in the morning after arising from bed

Who should do the Anti - CCP test (Target population)?

  • Persons showing the above signs & symptoms.
  • Person who has joint inflammation and/or undiagnosed or undifferentiated inflammatory arthritis, with symptoms that suggest but do not yet meet the criteria of RA

What should I do before the Anti - CCP by MEIA test?

Specimen type

Specimen collection procedure

Preparatory instructions before the test *

Serum (Blood Sample)


Collection of blood from a vein, usually from the arm

No Fasting Required.

No other special preparations required.

*Subjects suffering from any illness or on oral or injectable medications are advised to consult their physician prior to requesting any tests or procedures.

How do I interpret my Anti - CCP by MEIA test results?

Reference Range*


<17. 0 u/ml


>17.0 u/ml


‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’

Diseases/conditions related to the Anti - CCP by MEIA test

  • Rheumatoid arthritis
  • Undifferentiated arthritis

Other tests related to the Anti - CCP by MEIA test

  • Rheumatoid Factor

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Anti CCP (Antibody to Cyclic Citrullinated Peptide)