Anti TB antibodies - IgG / IgM

Clinical definition of the Anti TB test
The test is a screening assay for the qualitative differentiation of IgG and IgM antibodies to Mycobacterium Tuberculosis in human serum and plasma.
Tuberculosis is a disease caused by the bacteria Mycobacterium tuberculosis which usually attacks the lungs but can also affect other parts of the body. It may cause pulmonary tuberculosis and other infections such as those of the skin and abdomen. It is spread through the air when people who have the disease cough, sneeze, or spit.
The other widely used tests used in the diagnosis & screening of Tuberculosis infection are:

  • AFB, smear examination
  • Culture, Mycobacterium Tuberculosis
  • Mycobacterium antibody panel (TB-IgG, IgM, IgA)
  • Mycobacterium Tuberculosis by RT-PCR
  • Quantiferon TB Gold
  • Mantoux Test

Why is the Anti TB test done?
The Anti TB test (IgA, IgG, IgM) is limited to the qualitative detection of antibodies to Mycobacterium tuberculosis in human serum, plasma. It also recognizes antibodies of Mycobacterium bovis and Mycobacterium africanum. The test is a qualitative screening assay and is not for determining quantitative concentration of TB antibodies.

What are the common signs/symptoms when the Anti TB test is done?
These symptoms may be diagnosed by and screened for:

  • Unexplained weight loss
  • Fatigue
  • Fever
  • Night sweats
  • Chills
  • Loss of appetite
  • Prolonged and Persistent cough
  • Blood in sputum
  • Painful breathing
  • Painful coughing

When TB severely spreads in the lungs it shows the following symptoms include:

  • Chest pain, 
  • Coughing up blood,
  • Prolonged cough for more than three weeks

Who should do the Anti TB test (Target population)?
Persons showing the above signs & symptoms.

What should I do before the Anti TB test?

Specimen type

Specimen collection procedure

Preparatory instructions before the test *

Serum (Blood Sample)

Venipuncture - Collection of blood from a vein, usually from the arm.

No Fasting Required.

No other special preparations required.

*Subjects suffering from any illness or on oral or injectable medications are advised to consult their physician prior to requesting any tests or procedures.

How do I interpret my Anti TB test results?




Reference Range*


Reference Range*


Reference Range*


201 - 300 Sero Unit

Borderline Negative

125 - 225 Sero Unit


0.8 - 1.0 Index


301 - 350 Sero Unit

Borderline Positive

> 350 Sero Unit


> 225 Sero Unit


> 1.0 Index


< 200 Sero Unit


< 125 Sero Unit


< 0.8 Index


‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’

Diseases/conditions related to the Anti TB test

  • Tuberculosis

Other tests related to the Anti TB test

  • Acid Fast Baciili Culture Test
  • TB-PCR
  • Mantoux Test
  • Quantiferon TB Gold Test
  • Chest radiograph
  • Sputum smear
  • Molecular testing
  • Mycobacteria culture
  • Atypical mycobacterial infection
  • TB skin test

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TB (Mycobacterium Tuberculosis) IgM